Blood Bank:
Accurate blood typing and preparation of safe, compatible blood products.
Coagulation:
Assessment of blood clotting factors to evaluate the risk of bleeding or thrombosis; essential for cardiac patients and preoperative evaluations.
Biochemistry:
Precise measurement of glucose, lipids, enzymes, and electrolytes to monitor the function of vital organs such as the liver, kidneys, and heart using fully automated analyzers.
Pathology:
Microscopic examination of tissue and cellular specimens by expert pathologists for the definitive diagnosis of benign and malignant masses and lesions.
Urinalysis:
Microscopic and chemical examination of urine for the early detection of infections, kidney stones, diabetes, and urinary tract abnormalities.
Genetics
Dr. Nejat Mahdieh
Technical Director, Genetics Laboratory
Genetics Laboratory Specialists:
Ms. Tanaz Masoumi
Ms. Zohreh Hosseinkhani
Genetics Laboratory Direct Contact Number
021-23923033
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Who Should Consider Genetic Counseling?
Genetic counseling is an effective approach to the prevention, diagnosis, and management of inherited disorders. During this process, detailed information about the nature of a condition, its clinical manifestations, progression, and potential outcomes is reviewed.
A comprehensive family pedigree is constructed and inheritance patterns are analyzed to estimate the likelihood of a genetic condition occurring or recurring in an individual or other family members.
When necessary, additional evaluations may include molecular, chromosomal, laboratory, and imaging studies. Once the underlying cause is identified, evidence-based recommendations for prevention, monitoring, and treatment are provided according to each family's specific circumstances to support informed decision-making.
Genetic counseling is one of the most accessible and effective strategies for reducing the risk of congenital anomalies and hereditary diseases. It plays an important role in various medical specialties, including obstetrics and gynecology, infertility, cardiovascular medicine, oncology, neonatology, and hematology.
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When Is Genetic Counseling Recommended?
- Consanguineous marriages
- Pregnancy or marriage at an advanced age
- A recent diagnosis of a genetic disorder
- Recurrent miscarriages (particularly those associated with coagulation disorders such as Factor II and Factor V mutations)
- Infertility
- Carrier screening for common genetic disorders
- Having a child with congenital anomalies or intellectual disability
- Family history of inherited disorders such as cystic fibrosis, congenital heart defects, Fragile X syndrome, or diabetes
- Exposure to potentially harmful agents (medications, chemicals, alcohol, or radiotherapy)
- Personal or family concerns regarding genetic health
- Certain behavioral disorders with a suspected genetic basis
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Genetics Laboratory Services
Equipped with advanced technologies, the Genetics Laboratory provides comprehensive genetic diagnostic services, including prenatal and postnatal testing, at government-approved rates:
Molecular Genetics
Testing for a wide range of conditions, including:
- Metabolic disorders
- Cardiovascular diseases
- Hearing loss
- Male infertility
- Pregnancy loss and miscarriage
- Neuromuscular disorders
- Mitochondrial diseases
- Various types of cancer
- Other molecular disorders as requested by the treating physician
Cytogenetics and Karyotyping
Karyotype analysis is used to evaluate chromosome number and structure and to identify chromosomal abnormalities.
This test is recommended in the following situations:
- Congenital anomalies and birth defects
- Family history of chromosomal syndromes such as Down syndrome
- Infertility
- History of structural chromosomal abnormalities
- Abnormal prenatal screening results
- Developmental delay and growth disorders
- Recurrent miscarriages
- Menstrual disorders or amenorrhea
- Ambiguous genitalia
- History of neonatal death or stillbirth
- Chromosome instability disorders (such as Fanconi anemia, Ataxia-Telangiectasia, and Bloom syndrome)
- Intellectual disability
- Sex determination and Y-chromosome evaluation in selected cases
- Prenatal sex determination in special circumstances
- Families with a child affected by a disability
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Techniques Used in the Genetics Laboratory
- PCR and PCR-derived methods for DNA amplification and analysis
- DNA and RNA extraction from blood and saliva samples
- Agarose gel electrophoresis for DNA and RNA fragment analysis
- Sanger sequencing
- Karyotyping for chromosome number and structural analysis
- MLPA (Multiplex Ligation-dependent Probe Amplification)
- NGS (Next-Generation Sequencing) Data Analysis
Serology:
Detection of antibodies and antigens for the diagnosis of rheumatologic, autoimmune, and infectious diseases.
Infectious Diseases:
Rapid and sensitive detection of viral and infectious agents using modern molecular techniques.
Blood Gas Analysis:
Rapid measurement of oxygen, carbon dioxide, and arterial blood pH levels for accurate assessment of respiratory function and the body's acid-base balance.
Microbiology:
Culture and accurate identification of pathogenic bacteria and fungi, along with antimicrobial susceptibility testing to identify the most effective antibiotics.
Sample Collection:
Specimen collection performed by experienced staff in a calm, fully sterile environment with minimal discomfort.
Hematology:
Comprehensive analysis of blood cells for the diagnosis of various types of anemia, hematologic disorders, and cancers.
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